Fargesin is a bioactive lignan from Flos Magnoliae, an herb widely used in the treatment of allergic rhinitis, sinusitis, and headache in Asia.We sought to investigate whether fargesin ameliorates experimental inflammatory bowel disease (IBD) in mice.Oral administration of fargesin significantly attenuated the symptoms of dextran sulfate sodium (DS
Devil firefish Pterois miles is an invasive alien species which has severely impacted biodiversity and ecological processes in invaded areas of the Mediterranean.In recent years, its presence has been documented in several countries of the Adriatic Sea.Based on the negative ecological and socio-economic impacts in other areas of the Mediterranean S
This paper describes new Monte Carlo codes for proton transport simulations in complex geometrical forms and in materials of different composition.The SRNA codes were developed for three dimensional (3D) dose distribution calculation in proton therapy and dosimetry.The model of these codes is based on the theory of proton multiple scattering and a
Abstract Pseudo Nambu-Goldstone bosons (pNGBs) are attractive dark matter (DM) candidates, since they couple to the mariya b vol 3 Standard Model (SM) predominantly through derivative interactions.Thereby they naturally evade the strong existing limits inferred from DM direct detection experiments.Working in an effective field theory that includes
Abstract Covalent drugs can achieve high potency with long dosing intervals.However, concerns remain about side-effects associated with off-target reactivity.Combining macrocyclic peptides with covalent warheads provides a solution to minimise off-target reactivity: the peptide enables highly specific target binding, positioning a weakly reactive w